The Best Marijuana Strains in Kentucky

As of January 1st, Kentucky’s medical marijuana program has been fully live, and patients across the Commonwealth can now begin the process of getting certified and preparing for access to legal marijuana. While dispensaries are not open yet, qualified patients can already be evaluated by licensed physicians and submit their recommendations to the state to receive their medical marijuana card.

With marijuana possession now legal for patients with a valid card, up to eight ounces of marijuana in approved forms, it’s only a matter of time before dispensaries begin supplying patients with safe, lab-tested, and therapeutic strains. And while we wait for official strain menus from Kentucky dispensaries, it’s a great time to explore the best strains expected to help with qualifying medical conditions like chronic pain, anxiety, insomnia, and more.

What Makes a Marijuana Strain “The Best” for Medical Use?

For medical patients, the “best” marijuana strain isn’t necessarily the one with the highest THC content, it’s the one that provides targeted relief for their specific symptoms. Factors like THC to CBD ratios, terpene profiles, and consumption methods all play a role in how effective a strain is for your condition.

In Kentucky, the only forms of medical marijuana you can obtain are:

• edibles

• oils

• tinctures

• vapes

• raw plant material

Only individuals over the age of 21 are able to purchase vaping products. Additionally, Kentucky law prohibits individuals from consuming raw plant material by smoking. Because of this, patients will be selecting products based on strain extracts rather than smoking flower. Still, knowing which strains are known for specific effects will help patients make more informed choices once dispensaries open.

Anticipated Top Strains for Kentucky Medical Marijuana Patients

While we wait for Kentucky dispensaries to release their exact product lineups, here are some of the most popular and effective strains used in other state programs. These strains are known to support a range of qualifying conditions currently accepted in Kentucky’s program.

1. ACDC – High CBD, Low THC

• Best For: Pain relief, anxiety, inflammation, epilepsy

• THC/CBD Ratio: 1:20

• Expected Format: Oil, tincture, capsule

ACDC is a go-to strain for patients who want relief without psychoactive effects. With very low THC and high CBD content, it’s ideal for conditions like chronic pain, epilepsy, and anxiety. It’s also gentle enough for new marijuana patients who are cautious about feeling “high.”

2. Blue Dream – Balanced Hybrid

• Best For: Depression, chronic pain, fatigue

• THC Content: 18–24%

• Terpenes: Myrcene, pinene, caryophyllene

Blue Dream offers balanced, long-lasting relief that supports both body and mind. This sativa-dominant hybrid is popular for its calming effect. Patients with mood disorders or pain conditions often benefit from Blue Dream based products.

3. Granddaddy Purple – High THC Indica

• Best For: Insomnia, muscle spasms, appetite loss

• THC Content: 20–27%

• Terpenes: Linalool, myrcene

Known for its deep relaxation effects, Granddaddy Purple is often used by patients with severe insomnia or muscle-related conditions. It’s one of the top picks for end-of-day use when calming the body is a priority.

4. Harlequin – High CBD Hybrid

• Best For: Inflammation, stress, arthritis

• THC/CBD Ratio: 5:2 or 1:1

• Terpenes: Myrcene, pinene

Harlequin is another high-CBD strain favored by patients who need anti-inflammatory support or suffer from chronic anxiety. The relatively low THC content makes it ideal for daytime use with minimal mental impairment.

5. Runtz – High THC, Uplifting Hybrid

• Best For: PTSD, mood disorders, stress

• THC Content: 25–29%

• Terpenes: Limonene, caryophyllene

Runtz has become one of the most talked-about strains for its euphoric, energizing effects. It may be especially helpful for patients managing trauma, low mood, or stress-related conditions.

6. Northern Lights – Classic Indica

• Best For: Severe pain, insomnia, fibromyalgia

• THC Content: 18–23%

• Terpenes: Myrcene, beta-caryophyllene

A staple in medical marijuana programs across the U.S., Northern Lights is a deeply relaxing strain ideal for nighttime use. Its sedative effects make it a good match for patients with sleep disorders or nerve-related pain.

Why You Should Get Your Kentucky Medical Marijuana Card Now

Although dispensaries have not yet opened, Kentucky’s medical marijuana program is fully active, and eligible patients can get certified right now. Getting your medical marijuana card ahead of time is a smart move for several important reasons.

A valid medical marijuana card provides legal protection, allowing you to legally possess up to 8 ounces of marijuana in the state. Without this certification, you're not protected under Kentucky law, even if you have a qualifying condition. Second, certified patients will be first in line to purchase products when dispensaries open. Waiting to apply could mean facing delays or backlogs once sales begin. Lastly, the certification process includes personalized medical guidance. 

By meeting with one of our licensed physicians at our Louisville or Lexington office, you’ll receive a treatment plan tailored to your specific condition, including product recommendations and proper dosing strategies to help you get the best possible results.

Be Informed, Be Ready

While Kentucky patients wait for dispensaries to officially open their doors, there’s plenty to do in preparation. Knowing which marijuana strains work best for your medical condition will help you navigate your options more confidently once products become available.

And most importantly, don’t wait to get your medical marijuana card. By acting now, you ensure legal protection, early access, and expert guidance when it matters most. To learn more or book your appointment, visit our website and take the first step toward safe, legal, and effective marijuana treatment in Kentucky.

Get Access to Medical Marijuana in Kentucky

Medical marijuana is here, Kentucky, and we’re booking appointments now!

You can schedule your appointment to see our doctor at our Louisville or Lexington office. Schedule your appointment today to get your marijuana card and be the first to access dispensaries as soon as they open!

Don’t wait—secure your spot and start your journey toward relief. Subscribe to our newsletter for more updates on the program and dispensaries!